Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging

Prof. Rudi Wiesner of the University of Cologne, Germany discusses his recent paper ‘Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging’, published in Neuroendocrinology. Prof. Wiesner’s group investigate the mechanisms of mitochondrial loss of function and centres around deciphering this process to be able to slow it down and delay the resulting organ insufficiency. The group’s goal is to understand in detail how mitochondrial damage – in particular damage caused by mitochondrial DNA deletions – arises and how it leads to organ dysfunction by failure of single cells in a tissue.
Interview by Dr Julie Ann Lough