GnRH deficiency disease, Kallman Syndrome, and Hypogonadotropic Hypogonadism

Dr Anna Cariboni from The University of Milan discusses her work on rare GnRH deficiency disease, Kallman Syndrome, and Hypogonadotropic Hypogonadism, using gene knockout studies.  Interview by Dr Julie Ann Lough Oleari R., Lettieri A., Paganoni A., Zanieri L., Cariboni A. (2018). Semaphorin Signaling in GnRH Neurons: From Development to Disease. Neuroendocrinology. DOI:10.1159/000495916

Corticosteroid action in the brain: the potential of selective receptor modulation

Eva Viho, PhD student at Leiden University Medical Centre, talks to NEN about her recent publication “Corticosteroid action in the brain: the potential of selective receptor modulation.” Interview by Dr Julie Ann Lough Viho E.M.G., Buurstede J.C., Mahfouz A., Koorneef L.L., van Weert L.T.C.M., Houtman R., Hunt H.J., Kroon J., Meijer O.C. (2019). Corticosteroid action … Read more “Corticosteroid action in the brain: the potential of selective receptor modulation”

JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes

Dr Jimena Ferraris of the Karolinska Institute and the University of Buenos Aires talks with NEN about her recently published work in Neuroendocrinology on the identification of signal transduction pathways that may play a role in the pathogenesis of prolactinomas. Interview by Dr. Julie Ann Lough de Dios, N., Orrillo, S.J., Irizarri, M., Theas, M., … Read more “JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes”

Long-term Energy Deficit In Mice Causes Long-lasting 1 Hypothalamic Alterations After Recovery

Dr. Odile Viltart, Associate Professor, Université de Lille, INSERM Department of Psychiatry and Neuroscience, Paris, talks with NEN about her recently published paper in Neuroendocrinology, on the effects of long-term energy deficit and refeeding. Interview by Dr. Julie Ann Lough Méquinion M, Le Thuc O, Zgheib S, Alexandre D, Chartrel N, Rovère C, Hardouin P, … Read more “Long-term Energy Deficit In Mice Causes Long-lasting 1 Hypothalamic Alterations After Recovery”

Obesity in Labrador Retrievers Linked to POMC Gene Deletion

Dr. Eleanor Raffen, Wellcome Trust Clinical Research Fellow, University of Cambridge, talks with NEN about her research into obesity and the link with POMC gene deletion. Interview by Dr. Julie Ann Lough Raffan E, Dennis RJ, O’Donovan CJ, et al. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone … Read more “Obesity in Labrador Retrievers Linked to POMC Gene Deletion”

A Structural Magnetic Resonance Imaging Study in Transgender Persons on Cross-Sex Hormone Therapy

Sven Mueller from the Department of Experimental Clinical and Health Psychology, Ghent University, talks with NEN about his recent study of neuroanatomical differences in transgender persons after extended cross-sex hormone therapy. Interview by Dr. Julie Ann Lough Mueller SC, Landré L, Wierckx K, T’Sjoen G. A Structural Magnetic Resonance Imaging Study in Transgender Persons on … Read more “A Structural Magnetic Resonance Imaging Study in Transgender Persons on Cross-Sex Hormone Therapy”

IDO predicts death in Neuroendocrine Neoplasia

Prof. Joerg Schefold of the Bern University Hospital, Switzerland talks to NEN about his research and recent published findings where he investigated the predictive value of IDO activity, tryptophan levels, and downstream catabolites in a neuroendocrine neoplasm patient population. Interview by Dr. Julie Ann Lough Pschowski R, Pape UF, Fusch G, Fischer C, Jann H, … Read more “IDO predicts death in Neuroendocrine Neoplasia”

Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging

Prof. Rudi Wiesner of the University of Cologne, Germany discusses his recent paper ‘Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging’, published in Neuroendocrinology. Prof. Wiesner’s group investigate the mechanisms of mitochondrial loss of function and centres around deciphering this process to be able to slow it down and … Read more “Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging”

Social Separation and HPA recovery

In this episode we are joined by Jack Taylor to talk about his manuscript ‘Reunion behavior after social separation is associated with enhanced HPA recovery in young marmoset monkeys‘ published in Psychoneuroendocrinology. Jack is a doctoral student in the Department of Psychology, University of Nebraska at Omaha.

Maternal chemical exposure effects on the developing neuroendocrine system: timing of maternal exposure and fetal sex are important

Dr. Michelle Bellingham of The University of Glasgow talks with NEN about her recent published findings on how the timing of maternal chemical exposure and fetal sex are important for the developing neuroendocrine system. Interview by Dr. Julie Ann Lough Bellingham, M. , Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Cotinot, C., Rhind, S., Sharpe, R.M. and … Read more “Maternal chemical exposure effects on the developing neuroendocrine system: timing of maternal exposure and fetal sex are important”

Leptin and Taste Buds

In this latest episode we hear from first author, Tricia Meredith, on her paper ‘Leptin’s Effect on Taste Bud Calcium Responses and Transmitter Secretion‘ published in Chemical Senses. Tricia undertook this work during her postdoctoral work in the lab of Dr Stephen Roper in the Miller School of Medicine, University of Miami.

Voluntary Exercise Adapts the Hypothalamus-pituitary-thyroid Axis in Male Rats

In this episode we hear from Patricia Joseph-Bravo, on how voluntary exercise can adapt the hypothalamus-pituitary-thyroid axis and the potential implications this has for humans, especially in relation to obesity. This talk focuses on her article ‘Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats’, published in Endocrinology. Patricia is a Group Head at the National … Read more “Voluntary Exercise Adapts the Hypothalamus-pituitary-thyroid Axis in Male Rats”

Health Outcomes in Acromegaly: Depression and Anxiety – with Victor Geraedts

In today’s episode we take a look at the health outcomes in Acromegaly and how depression and anxiety are potential targets for improving reduced quality of life in patients. We are joined by Victor Geraedts, a guest researcher at the Max Planck Institue for Psychiatry, Munich and a Medical Intern at Leiden University Medical Center. … Read more “Health Outcomes in Acromegaly: Depression and Anxiety – with Victor Geraedts”

Diet Induced Hyperleptinemia and Ghrelin Resistance

In this episode of NeuroEndoNow Dr Zane Andrews from Monash University discusses his paper published in Neuroendocrinology on ‘Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.‘ Dr Andrews studies how the brain regulates food intake and body weight during different metabolic states and in response to … Read more “Diet Induced Hyperleptinemia and Ghrelin Resistance”

Restoration of Glucocorticoid Sensitivity Through Inhibition of HSP90

In this latest episode of NeuroEndoNow senior author Dr Marcelo Paez-Pereda discusses his recent paper ‘A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.’ published in Nature Medicine. Marcelo Paez-Pereda is an award-winning neuroendocrinologist at the Max Planck Institute of Psychiatry in Munich, Germany. In 2010, he was appointed as Coordinator of Technology Transfer. … Read more “Restoration of Glucocorticoid Sensitivity Through Inhibition of HSP90”

Regulation of Growth Hormone by NPY

In this podcast we talk with Professor Chen and Dr Steyn on their recent work ‘Actions of NPY, and its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State’ recently published in Journal of Neuroscience. You can download a copy of the paper here .